The Destination Medical Center plan for Rochester is big, bold, and ambitious. The $6 billion vision calls for growing the Mayo Clinic’s campus while also drawing other development such as hotels and housing. The tab is being paid by Mayo, private investors, and $585 million from the state of Minnesota. Lisa Clarke, a 17-year veteran of Mayo Clinic, has been leading the charge. She’s a high-energy cheerleader for the city but also has a reputation for a get-it-done focus. Changes are starting to show with a new $125 million Hilton Hotel and the $35 million One Discovery Square, a life science center.