Mayo Clinic’s Rochester campus is set to undergo a massive $5 billion redesign.

On Tuesday afternoon, the health system announced that its board of trustees has officially approved the makeover. Mayo unveiled initial plans over the summer and released more details this week.

In a news release, Mayo officials said the plan calls for constructing five new buildings centered on “care neighborhoods.” The idea is to create groupings for patients with similar needs and conditions.

“We see a future state where the care we provide is so continuous — and supported by emerging technologies that connect us more meaningfully to patients — that the very definitions of ‘hospital’ and ‘clinic’ are blurred, leading to further innovation and transformation,” said Dr. Amy Williams, executive dean of practice for Mayo Clinic.

Mayo officials refer to the plan as “Bold. Forward. Unbound. in Rochester.”

The Star Tribune reports that the project involves the demolition of existing buildings to make way for the new ones. The project also includes two new patient parking ramps that will provide a total of 1,300 spaces.

Mayo officials noted that preparatory work is already underway, with major construction slated to begin in 2024. The project is expected to wrap up by 2030, though some new facilities could open as soon as 2028.

One of the new buildings will be a logistics center in the former Lourdes High School site, which will be designed to “accommodate Mayo Clinic’s long-term growth and ensure that clinical space can be used for patient care,” Mayo officials said.

All of the new buildings are designed with flexibility in mind, according to Mayo. In a “first-of-its-kind” for a health care campus, the new buildings will be able to shift to suit different needs as they arise. “In a typical hospital building, certain floors and spaces are designed for surgery, others for hospital beds, and others for imaging support,” Mayo officials noted. “In Mayo Clinic’s new clinical buildings, specific spaces or entire floors will be able to shift from patient room to operating room, to diagnostic imaging suite as needs change over time.”

The Rochester makeover is being carried out in tandem with updates to Mayo’s campuses in other states, including sites in Arizona, Florida, and Wisconsin. Mayo officials said projects are already “well underway” at those locations. The broader aim is to “achieve seamless integration of physical spaces and digital capabilities,” according to Mayo.

Mayo’s massive redesign is going forward even after the health system threatened to cancel it in response to proposed legislative changes.